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J Invest Dermatol. 2011 May;131(5):1005-7. doi: 10.1038/jid.2011.51.

Oxidatively generated damage to DNA by UVA radiation in cells and human skin.

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1
Laboratoire Lésions de Acides Nucléiques, SCIB-UMR-E no 3, CEA/UJF, FRE CNRS 3200, Département de Recherche Fondamentale sur la Matière Condensée, Grenoble, France. jean.cadet@cea.fr

Abstract

Exposure of cells and human skin to UVA radiation oxidatively induces damage to DNA that consists mostly of 8-oxo-7,8-dihydroguanine (8-oxoGua), together with relatively minor amounts of oxidized pyrimidine bases and oligonucleotide strand breaks. Singlet oxygen generated by the type II photosensitization mechanism forms 8-oxoGua, with a small contribution by hydroxyl radicals. The mechanisms of UVA-mediated formation of DNA oxidation products indicate the absence of induction of double-strand breaks.

PMID:
21494240
DOI:
10.1038/jid.2011.51
[Indexed for MEDLINE]
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