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J Occup Environ Med. 2011 May;53(5):506-10. doi: 10.1097/JOM.0b013e31821854da.

Toenail, blood, and urine as biomarkers of manganese exposure.

Author information

1
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA. wisanti@post.harvard.edu

Abstract

OBJECTIVE:

This study examined the correlation between manganese exposure and manganese concentrations in different biomarkers.

METHODS:

Air measurement data and work histories were used to determine manganese exposure over a work shift and cumulative exposure. Toenail samples (n = 49), as well as blood and urine before (n = 27) and after (urine, n = 26; blood, n = 24) a work shift were collected.

RESULTS:

Toenail manganese, adjusted for age and dietary manganese, was significantly correlated with cumulative exposure in 7 to 9, 10 to 12, and 7 to 12 months before toenail clipping date, but not 1 to 6 months. Manganese exposure over a work shift was not correlated with changes in blood nor urine manganese.

CONCLUSIONS:

Toenails appeared to be a valid measure of cumulative manganese exposure 7 to 12 months earlier. Neither change in blood nor urine manganese appeared to be suitable indicators of exposure over a typical work shift.

PMID:
21494156
PMCID:
PMC3092003
DOI:
10.1097/JOM.0b013e31821854da
[Indexed for MEDLINE]
Free PMC Article
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