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Bioorg Med Chem Lett. 2011 May 15;21(10):2911-5. doi: 10.1016/j.bmcl.2011.03.069. Epub 2011 Mar 31.

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists.

Author information

1
Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. liping_wang@merck.com

Abstract

A series of six-membered heterocycle carboxamides were synthesized and evaluated as cholecystokinin 1 receptor (CCK1R) agonists. A pyrimidine core proved to be the best heterocycle, and SAR studies resulted in the discovery of analog 5, a potent and structurally diverse CCK1R agonist.

PMID:
21493064
DOI:
10.1016/j.bmcl.2011.03.069
[Indexed for MEDLINE]

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