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Case Rep Gastroenterol. 2008 Jul 9;2(2):238-43. doi: 10.1159/000142739.

A Pancreatic Polypeptide-Producing Pancreatic Tumor Causing WDHA Syndrome.

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1
Department of Surgery, Philipps University Marburg, Marburg, Germany.

Abstract

We report the case of a 46-year-old female patient with WDHA (watery diarrhea/hypokalemia/achlorhydria) syndrome caused by a pancreatic polypeptide-producing tumor in the head of the pancreas. Whereas VIP and other pancreatic endocrine hormones were in the normal range, only serum levels of pancreatic polypeptide were elevated. Imaging studies identified a pancreatic tumor in the head of the gland. After laparotomy, the tumor of 3 cm in size was enucleated. Final pathology documented a pancreatic endocrine tumor with immunohistochemical staining demonstrating the presence of pancreatic polypeptide. The patient remained cured after a follow-up of more than three years. The present case illustrates that, although rare, WDHA syndrome may be associated with a pancreatic polypeptide-secreting endocrine tumor of the pancreas.

KEYWORDS:

Endocrine pancreatic tumor; Pancreatic polypeptide; WDHA syndrome

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