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PLoS Genet. 2011 Apr;7(4):e1002033. doi: 10.1371/journal.pgen.1002033. Epub 2011 Apr 7.

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

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1
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.

Abstract

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

PMID:
21490707
PMCID:
PMC3071630
DOI:
10.1371/journal.pgen.1002033
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

The authors have declared that no competing interests exist.

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