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Nat Chem Biol. 2011 Apr 13;7(7):428-30. doi: 10.1038/nchembio.573.

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.

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1
Vertex Pharmaceuticals (Europe), Abingdon, Oxfordshire, UK.

Abstract

Here we report a comprehensive biological characterization of a potent and selective small-molecule inhibitor of the DNA damage response (DDR) kinase ATR. We show a profound synthetic lethal interaction between ATR and the ATM-p53 tumor suppressor pathway in cells treated with DNA-damaging agents and establish ATR inhibition as a way to transform the outcome for patients with cancer treated with ionizing radiation or genotoxic drugs.

PMID:
21490603
DOI:
10.1038/nchembio.573
[Indexed for MEDLINE]

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