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Kidney Int. 2011 Jun;79(12):1277-88. doi: 10.1038/ki.2011.95. Epub 2011 Apr 13.

Intracellular cAMP signaling by soluble adenylyl cyclase.

Author information

1
Marine Biology Research Division, Scripps Institution of Oceanography, University of California San Diego, La Jolla, California, USA.

Abstract

Soluble adenylyl cyclase (sAC) is a recently identified source of the ubiquitous second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is distinct from the more widely studied source of cAMP, the transmembrane adenylyl cyclases (tmACs); its activity is uniquely regulated by bicarbonate anions, and it is distributed throughout the cytoplasm and in cellular organelles. Due to its unique localization and regulation, sAC has various functions in a variety of physiological systems that are distinct from tmACs. In this review, we detail the known functions of sAC, and we reassess commonly held views of cAMP signaling inside cells.

PMID:
21490586
PMCID:
PMC3105178
DOI:
10.1038/ki.2011.95
[Indexed for MEDLINE]
Free PMC Article

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