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Curr Opin Chem Biol. 2011 Jun;15(3):350-4. doi: 10.1016/j.cbpa.2011.03.004. Epub 2011 Apr 12.

Role of natural product diversity in chemical biology.

Author information

1
Department of Chemistry, Duke University, Durham, NC 27708, USA. jiyong.hong@duke.edu

Abstract

Through the natural selection process, natural products possess a unique and vast chemical diversity and have been evolved for optimal interactions with biological macromolecules. Owing to their diversity, target affinity, and specificity, natural products have demonstrated enormous potential as modulators of biomolecular function, been an essential source for drug discovery, and provided design principles for combinatorial library development.

PMID:
21489856
PMCID:
PMC3110584
DOI:
10.1016/j.cbpa.2011.03.004
[Indexed for MEDLINE]
Free PMC Article
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