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Org Lett. 2011 May 6;13(9):2274-7. doi: 10.1021/ol200716d. Epub 2011 Apr 13.

Ruthenium-catalyzed oxidation of alkenes at room temperature: a practical and concise approach to α-diketones.

Author information

1
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.

Abstract

The catalytic oxidation of alkenes to α-diketones is unprecedented. A new oxidation of alkenes, catalyzed by a ruthenium complex, which allows an efficient route to α-diketones using TBHP as an oxidant is described. This methodology is highly functional group tolerant, is practically convenient, requires no additional ligand, and operates under mild conditions with short reaction times. Based upon experimental observations, a plausible mechanism is proposed.

PMID:
21488675
DOI:
10.1021/ol200716d

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