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Yonsei Med J. 2011 May;52(3):543-6. doi: 10.3349/ymj.2011.52.3.543.

Effect of zoledronic acid on acro-osteolysis and osteoporosis in a patient with Hajdu-Cheney syndrome.

Author information

1
Department of Internal Medicine, Yonsei University College of Medicine, Seodaemun-gu, Seoul 102-752, Korea.

Abstract

Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself.

PMID:
21488202
PMCID:
PMC3101052
DOI:
10.3349/ymj.2011.52.3.543
[Indexed for MEDLINE]
Free PMC Article

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