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J Dent Res. 2011 Sep;90(9):1070-7. doi: 10.1177/0022034511405330. Epub 2011 Apr 12.

Dynamics of salivary gland morphogenesis.

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1
Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bldg. 30, Room 426, 30 Convent Drive, MSC 4370, Bethesda, MD 20892-4370, USA.

Abstract

Salivary glands form during embryonic development by a complex process that creates compact, highly organized secretory organs with functions essential for oral health. The architecture of these glands is generated by branching morphogenesis, revealed by recent research to involve unexpectedly dynamic cell motility and novel regulatory pathways. Numerous growth factors, extracellular matrix molecules, gene regulatory pathways, and mechanical forces contribute to salivary gland morphogenesis, but local gene regulation and morphological changes appear to play particularly notable roles. Here we review these recent advances and their potential application to salivary gland tissue engineering.

PMID:
21487116
PMCID:
PMC3318079
DOI:
10.1177/0022034511405330
[Indexed for MEDLINE]
Free PMC Article
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