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Physiology (Bethesda). 2011 Apr;26(2):106-14. doi: 10.1152/physiol.00039.2010.

Heterogeneous cardiac proteasomes: mandated by diverse substrates?

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1
Departments of Physiology and Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Abstract

Proteasome biology has taken central stage in cardiac physiology and pathophysiology. The molecular heterogeneity of proteasome subpopulations supports the specificity of proteasome function to degrade diverse substrate repertoires. Unveiling the dynamics of proteasome function should inspire new therapeutic strategies for combating cardiac disease.

PMID:
21487029
DOI:
10.1152/physiol.00039.2010
[Indexed for MEDLINE]
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