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Org Lett. 2011 May 6;13(9):2298-301. doi: 10.1021/ol2004885. Epub 2011 Apr 12.

Rapid determination of enantiomeric excess of α-chiral cyclohexanones using circular dichroism spectroscopy.

Author information

1
Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, United States.

Abstract

Ketone handedness was discriminated using circular dichroism (CD) spectroscopy by monitoring the metal-to-ligand charge transfer (MLCT) bands of complexes between [Cu(I)((S)-1)(CH(3)CN)(2)]PF(6) and derivatized α-chiral cyclohexanones (4). This method was able to quantify the enantiomeric excess of unknown samples using a calibration curve, giving an absolute error of ±7%. The analysis was fast, allowing potential application of this assay in high-throughput screening (HTS).

PMID:
21486023
PMCID:
PMC3097997
DOI:
10.1021/ol2004885
[Indexed for MEDLINE]
Free PMC Article

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