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J Agric Food Chem. 2011 May 25;59(10):5595-601. doi: 10.1021/jf2005707. Epub 2011 May 4.

Inhibitory effect of açaí (Euterpe oleracea Mart.) pulp on IgE-mediated mast cell activation.

Author information

1
Laboratory of Biochemistry, Graduate School of Life Science, Kobe Women's University, Kobe, Japan.

Abstract

The palm fruit açaí is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, açaí suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured mast cell line of rat basophilic leukemia (RBL)-2H3 cells. Açaí could selectively inhibit FcεRI signaling pathways. Furthermore, the FcεRI-mediated complementary signaling pathway was also suppressed by açaí. These results demonstrate that açaí is a potent inhibitor of IgE-mediated mast cell activation.

PMID:
21486000
DOI:
10.1021/jf2005707
[Indexed for MEDLINE]

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