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J Med Entomol. 2011 Mar;48(2):389-94.

Interactions between La Crosse virus and bacteria isolated from the digestive tract of Aedes albopictus (Diptera: Culicidae).

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Department of Biology, Radford University, Radford, VA 24142, USA.


Aedes albopictus (Skuse) is a potential vector for many arboviruses, including La Crosse virus (LACV), the leading cause of pediatric encephalitis in North America. Bacteria isolated from the midgut and diverticula of field-caught female Ae. albopictus were cultured and identified using 16S ribosomal RNA gene amplification and sequencing. Members of seven and six bacterial families were identified from the midguts and diverticula, respectively, with nearly half of the isolates identified to the family Enterobacteriaceae. Many are related to bacteria identified in other invertebrates, and several may represent previously unknown species or genera. Of the 24 isolated bacteria, 12 (50%) showed a significant reduction in infectivity of LACV for Vero cells. Inhibition of infectivity ranged from 0 to 44% and was not dependent on bacterial classification. The antiviral activity of these bacteria warrants further investigation as an alternate means to interrupt the LACV transmission cycle.

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