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Chem Commun (Camb). 2011 May 21;47(19):5485-7. doi: 10.1039/c1cc10316d. Epub 2011 Apr 11.

Fluorescence turn-on detection of a protein through the displaced single-stranded DNA binding protein binding to a molecular beacon.

Author information

1
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.

Abstract

A new approach has been developed for the highly sensitive and selective sensing of a protein. Lysozyme binding to its aptamer prevents SSB protein binding, and the subsequent binding of the free SSB protein to a molecular beacon results in a turn-on fluorescence signal, which can be used for lysozyme quantification.

PMID:
21483905
DOI:
10.1039/c1cc10316d
[Indexed for MEDLINE]

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