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Aging (Albany NY). 2011 Apr;3(4):450-4.

Hyperactive when young, hypoactive and overweight when aged: connecting the dots in the story about locomotor activity, body mass, and aging in Trpv1 knockout mice.

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Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA.


We have recently found that, at a young age, transient receptor potential vanilloid-1 (Trpv1) knockout (-/-) mice have a higher locomotor activity than their wild-type littermates (+/+). We have also found that, with age, Trpv1(-/-) mice become substantially heavier than Trpv1(+/+) controls, thus forming a paradoxical association between locomotor hyperactivity and overweight. The present study solves this contradiction. By using two experimental paradigms, we show that aged Trpv1(-/-) mice have not an increased, but a decreased, locomotor activity, as compared to age-matched Trpv1(+/+) controls. We also confirm that aged Trpv1(-/-) mice are overweight. We conclude that TRPV1 channels are involved in the regulation of both general locomotor activity and body mass in an age-dependent manner.

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