Format

Send to

Choose Destination
Neuron. 2011 Apr 14;70(1):43-50. doi: 10.1016/j.neuron.2011.02.044.

Reevaluating the role of LTD in cerebellar motor learning.

Author information

1
Department of Neuroscience, Dr Molewaterplein 50, Erasmus MC, 3015 GE Rotterdam, The Netherlands.

Abstract

Long-term depression at parallel fiber-Purkinje cell synapses (PF-PC LTD) has been proposed to be required for cerebellar motor learning. To date, tests of this hypothesis have sought to interfere with receptors (mGluR1) and enzymes (PKC, PKG, or αCamKII) necessary for induction of PF-PC LTD and thereby determine if cerebellar motor learning is impaired. Here, we tested three mutant mice that target the expression of PF-PC LTD by blocking internalization of AMPA receptors. Using three different cerebellar coordination tasks (adaptation of the vestibulo-ocular reflex, eyeblink conditioning, and locomotion learning on the Erasmus Ladder), we show that there is no motor learning impairment in these mutant mice that lack PF-PC LTD. These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning.

PMID:
21482355
PMCID:
PMC3104468
DOI:
10.1016/j.neuron.2011.02.044
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center