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Curr Opin Struct Biol. 2011 Jun;21(3):441-6. doi: 10.1016/j.sbi.2011.02.005. Epub 2011 Apr 7.

Evolution and disorder.

Author information

1
Department of Biological Sciences, IBEST, University of Idaho, Moscow, ID 83844-3051, United States. celesteb@uidaho.edu

Abstract

The evolution of disordered proteins or regions of proteins differs from that of ordered proteins because of the differences in their sequence composition, intramolecular contacts, and function. Recent assessments of disordered protein evolution at the sequence, structural, and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordered proteins. Even with these high rates of sequence evolution, a few examples have shown that disordered proteins maintain their flexibility under physiological conditions, and it is hypothesized that they maintain specific structural ensembles.

PMID:
21482101
PMCID:
PMC3112239
DOI:
10.1016/j.sbi.2011.02.005
[Indexed for MEDLINE]
Free PMC Article
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