Format

Send to

Choose Destination
Cancer Cell. 2011 Apr 12;19(4):541-55. doi: 10.1016/j.ccr.2011.02.006.

CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.

Author information

1
Breast Tumor Center, Sun-Yat-Sen Memorial Hospital, Sun-Yat-Sen University, Guangzhou, China.

Erratum in

  • Cancer Cell. 2011 Jun 14;19(6):814-6.

Abstract

Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhancing their adherence to extracellular matrix. Furthermore, we identify PITPNM3 as a functional receptor for CCL18 that mediates CCL18 effect and activates intracellular calcium signaling. CCL18 promotes the invasion and metastasis of breast cancer xenografts, whereas suppressing PITPNM3 abrogates these effects. These findings indicate that CCL18 derived from TAMs plays a critical role in promoting breast cancer metastasis via its receptor, PITPNM3.

Comment in

PMID:
21481794
PMCID:
PMC3107500
DOI:
10.1016/j.ccr.2011.02.006
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center