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Cancer Cell. 2011 Apr 12;19(4):429-31. doi: 10.1016/j.ccr.2011.03.018.

The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment.

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Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.


Tumor-associated inflammation is a consequence and a driver of tumorigenesis. Three papers in this issue of Cancer Cell demonstrate the importance of tumor-elicited inflammation in the development and progression of pancreatic ductal adenocarcinoma and esophageal squamous carcinoma. Disruption of tissue homeostasis culminates in activation of STAT3, generating a pro-tumorigenic inflammatory microenvironment.

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