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Bioconjug Chem. 2011 May 18;22(5):859-64. doi: 10.1021/bc2000947. Epub 2011 Apr 19.

Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide.

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  • 1Division of Diagnostic Oncology, The Netherlands Cancer Institute , Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Abstract

The antagonistic Ac-TZ14011 peptide, which binds to the chemokine receptor 4, has been labeled with a multifunctional single attachment point reagent that contains a DTPA chelate and a fluorescent dye with Cy5.5 spectral properties. Flow cytometry and confocal microscopy showed that the bimodal labeled peptide gave a specific receptor binding that is similar to monofunctionalized peptide derivatives. Therefore, the newly developed bimodal peptide derivative can be used in multimodal imaging applications.

PMID:
21480671
PMCID:
PMC3711080
DOI:
10.1021/bc2000947
[PubMed - indexed for MEDLINE]
Free PMC Article
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