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Chem Res Toxicol. 2011 Jun 20;24(6):781-90. doi: 10.1021/tx200064a. Epub 2011 Apr 21.

Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes.

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1
Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, United States. hecht002@umn.edu

Abstract

This perspective reviews our work on the identification of DNA adducts of N-nitrosopyrrolidine and some related aldehydes. The research began as a focused project to investigate mechanisms of cyclic nitrosamine carcinogenesis but expanded into other areas, as aldehyde metabolites of NPYR were shown to have their own diverse DNA adduct chemistry. A total of 69 structurally distinct DNA adducts were identified, and some of these, found in human tissues, have provided intriguing leads for investigating carcinogenesis mechanisms in humans due to exposure to both endogenous and exogenous agents.

PMID:
21480629
PMCID:
PMC3118975
DOI:
10.1021/tx200064a
[Indexed for MEDLINE]
Free PMC Article
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