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Hepatology. 2011 Apr;53(4):1377-87. doi: 10.1002/hep.24229.

Drug-induced cholestasis.

Author information

1
Division of Gastroenterology, Centennial Hills Hospital Medical Center, Las Vegas, NV, USA.

Abstract

Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.

PMID:
21480339
PMCID:
PMC3089004
DOI:
10.1002/hep.24229
[Indexed for MEDLINE]
Free PMC Article

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