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Opt Lett. 2011 Apr 1;36(7):1236-8. doi: 10.1364/OL.36.001236.

Multifocal optical-resolution photoacoustic microscopy in vivo.

Author information

1
Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA.

Abstract

Although ultrasound arrays have been exploited in photoacoustic imaging to improve imaging speed, ultrasound-array-based optical-resolution photoacoustic microscopy (OR-PAM) has never been achieved previously to our knowledge. Here we present our development of multifocal OR-PAM using a microlens array for optical illumination and an ultrasound array for photoacoustic detection. Our system is capable of imaging hemoglobin concentration and oxygenation in individual microvessels in vivo at high speed. Compared with a single focus, multiple foci reduce the scanning load and increase the imaging speed significantly. The current multifocal system can acquire 1000 × 500 × 200 voxels at ~10 μm lateral resolution within 4 min.

PMID:
21479041
PMCID:
PMC3093968
DOI:
10.1364/OL.36.001236
[Indexed for MEDLINE]
Free PMC Article

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