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Cell Cycle. 2011 May 15;10(10):1582-9. Epub 2011 May 15.

Thrombopoietin and hematopoietic stem cells.

Author information

1
The Walter and Eliza Hall Institute, Parkville, Victoria, Australia.

Abstract

Thrombopoietin (TPO) is the cytokine that is chiefly responsible for megakaryocyte production but increasingly attention has turned to its role in maintaining hematopoietic stem cells (HSCs). HSCs are required to initiate the production of all mature hematopoietic cells, but this differentiation needs to be balanced against self-renewal and quiescence to maintain the stem cell pool throughout life. TPO has been shown to support HSC quiescence during adult hematopoiesis, with the loss of TPO signaling associated with bone marrow failure and thrombocytopenia. Recent studies have shown that constitutive activation mutations in Mpl contribute to myeloproliferative disease. In this review, we will discuss TPO signaling pathways, regulation of TPO levels and the role of TPO in normal hematopoiesis and during myeloproliferative disease.

PMID:
21478671
PMCID:
PMC3127159
DOI:
10.4161/cc.10.10.15619
[Indexed for MEDLINE]
Free PMC Article
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