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Heart. 2011 Jul;97(13):1034-40. doi: 10.1136/hrt.2010.215350. Epub 2011 Apr 8.

Prevention of atrial fibrillation with omega-3 fatty acids: a meta-analysis of randomised clinical trials.

Author information

1
The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Abstract

CONTEXT:

Previous randomised controlled trials (RCT) regarding n-3 PUFA supplementation for atrial fibrillation (AF) prevention have yielded conflicting results.

OBJECTIVE:

A systematic review and meta-analysis of RCT was conducted to examine the role of n-3 PUFA in AF prevention.

DATA SOURCES:

MEDLINE, Web of Science and Cochrane clinical trials database were searched until November 2010.

STUDY SELECTION:

Of 127 initially identified studies, 10 RCT with 1955 patients were finally analysed.

DATA EXTRACTION:

Two blinded reviewers extracted data independently to a predefined form. Disagreements were resolved through discussion and consensus.

RESULTS:

n-3 PUFA had no significant effect on the prevention of AF (OR 0.81, 95% CI 0.57 to 1.15; p=0.24). There was significant heterogeneity among the studies (p=0.002, I(2)=65.0%). Subgroup analysis showed no significant beneficial effect of fish oils in any subset of population.

CONCLUSIONS:

No significant effects of n-3 PUFA supplementation on AF prevention were observed in this meta-analysis. A large-scale trial with higher doses and longer follow-up might be required to rule out the possibility of any treatment benefit.

PMID:
21478384
DOI:
10.1136/hrt.2010.215350
[Indexed for MEDLINE]

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