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Exp Biol Med (Maywood). 2011 May 1;236(5):546-56. doi: 10.1258/ebm.2011.010360. Epub 2011 Apr 8.

The emerging role of autophagy in alcoholic liver disease.

Author information

1
Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center, Kansas City, 66160, USA. wxding@kumc.edu

Abstract

Autophagy is a highly conserved intracellular catabolic pathway that degrades cellular long-lived proteins and organelles. Autophagy is normally activated in response to nutrient deprivation and other stresses as a cell survival mechanism. Accumulating evidence indicates that autophagy plays a critical role in liver pathophysiology, in addition to maintaining hepatic energy and nutrient balance. Alcohol consumption causes hepatic metabolic changes, oxidative stress, accumulation of lipid droplets and damaged mitochondria; all of these can be regulated by autophagy. This review summarizes the recent findings about the role and mechanisms of autophagy in alcoholic liver disease (ALD), and the possible intervention for treating ALD by modulating autophagy.

PMID:
21478210
PMCID:
PMC4096159
DOI:
10.1258/ebm.2011.010360
[Indexed for MEDLINE]
Free PMC Article
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