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Folia Histochem Cytobiol. 2010 Dec;48(4):597-602. doi: 10.2478/v10042-010-0078-z.

Molecular differences in the KRAS gene mutation between a primary tumor and related metastatic sites - case report and a literature review.

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Department of Gastrointestinal Cancer, Cancer Center-Institute, Warsaw, Poland.


In recent years the the set of diagnostic tools in colorectal cancers has been extended by the assessment of the KRAS gene status. Currently it is a necessary step in order to qualify patients for the targeted therapy. The results of the analysis of several studies revealed a high rate of compliance of the KRAS gene mutational status in primary and metastatic tumors. In this paper we present a rare case of incompatibility of the KRAS mutations in the primary tumor located in the colon and metastatic changes in the liver.

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