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J Med Food. 2011 Jul-Aug;14(7-8):866-9. doi: 10.1089/jmf.2010.0164. Epub 2011 Apr 10.

In vitro amoebicidal activity of borage (Borago officinalis) extract on Entamoeba histolytica.

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Faculty of Biological Sciences, Universidad Autonoma de Nuevo Leon, Pedro de Alba y Manuel L. Barragan, Ciudad Universitaria, San Nicolas de los Garza, Nuevo Leon, Mexico.


Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC₅₀) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC₅₀ of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.

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