The American Occupational Therapy Association (AOTA) has challenged occupational therapy practitioners to advance the profession so that we may become more "powerful" and "widely recognized" by the year 2017 (AOTA, 2007a). To fully achieve this vision, this article argues that the profession should encourage occupational therapy entrepreneurship. As Herz, Bondoc, Richmond, Richman, and Kroll (2005, p.2) stated, "Entrepreneurship may provide us with the means to achieve the outcomes we need to succeed in the current health care environment." This article also argues the urgency of seizing the many opportunities that entrepreneurship offers and recommends specific actions to be taken by AOTA and by therapists.