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Case Rep Oncol. 2011 Feb 16;4(1):88-95. doi: 10.1159/000324717.

Pure small cell carcinoma of the prostate: a case report and literature review.

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Radiation Therapy Department, University Hospital of Ioannina, Ioannina, Greece.


Primary small cell carcinoma of the prostate (SCPCa) is a rare pathologic entity with unique clinical features and a poor prognosis. We present a case of a patient diagnosed with pure SCPCa treated with a combined chemo-radiotherapeutic approach. Pathological findings showed that the neoplastic cells exhibited positivity for pancytokeratin, synaptophysin, thyroid transcription factor-1 and CD56. Immunostaining for prostate-specific antigen was negative, while serum prostate-specific antigen was within normal limits. We review the available literature to gain additional information about diagnosis, treatment and prognosis of pure SCPCa.


Neuroendocrine differentiation; Prostate cancer; Small cell carcinoma

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