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J Surg Oncol. 2011 Sep 1;104(3):260-4. doi: 10.1002/jso.21936. Epub 2011 Apr 6.

Honokiol produces anti-neoplastic effects on melanoma cells in vitro.

Author information

1
Department of Surgery, University of Vermont/Fletcher Allen Health Care, Burlington, Vermont, USA. patrick.mannal@vtmednet.org

Abstract

BACKGROUND:

Melanoma continues to be a therapeutic challenge for the medical community owing to the scarcity of effective agents available to treat the disease. Honokiol, a traditional Chinese herb, has been proven to have anti-cancer effects in various cell types, therefore we hypothesized it may have similar cytotoxic capabilities against melanoma cells in vitro.

METHODS:

Two cell lines, SK-MEL2 and MeWo, were grown in culture and exposed to increasing doses of Honokiol. Cell proliferation, cytochrome c release into the cytosol, intra-cellular caspase activity, and mitochondrial depolarization were then evaluated after treatment with honokiol.

RESULTS:

Melanoma cells in culture underwent cell death, had increased cytosolic cytochrome c, showed greater caspase activity, and demonstrated increased mitochondrial depolarization after treatment when compared to controls.

CONCLUSIONS:

It appears that honokiol is an effective inhibitor of cultured human melanoma cells.

PMID:
21472732
DOI:
10.1002/jso.21936
[Indexed for MEDLINE]

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