Format

Send to

Choose Destination
Nature. 1990 Dec 6;348(6301):515-20.

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A.

Author information

1
MRC Laboratory of Molecular Biology, Cambridge, UK.

Abstract

The crystal structure of the RNA binding domain of the U1 small nuclear ribonucleoprotein A, which forms part of the ribonucleoprotein complex involved in the excision of introns, has been solved. It contains a four-stranded beta sheet and two alpha helices. The highly conserved segments designated RNP1 and RNP2 lie side by side on the middle two beta strands. U1 RNA binding studies of mutant proteins suggest that the RNA binds to the four-stranded beta sheet and to the flexible loops on one end.

PMID:
2147232
DOI:
10.1038/348515a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center