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Hong Kong Med J. 2011 Apr;17(2):112-8.

Stereotactic radiotherapy for hepatocellular carcinoma: report of a local single-centre experience.

Author information

1
Department of Clinical Oncology, Prince of Wales Hospital, Shatin, Hong Kong. lc_chan@clo.cuhk.edu.hk

Abstract

OBJECTIVE:

To evaluate the efficacy and toxicities of stereotactic radiotherapy for unresectable hepatocellular carcinoma.

DESIGN:

Retrospective study.

SETTING:

Prince of Wales Hospital, Hong Kong.

MAIN OUTCOME MEASURES:

Treatment outcome and toxicities.

PATIENTS:

During the period of 2000 to 2004, 16 patients with hepatocellular carcinoma treated with stereotactic radiotherapy were reviewed.

RESULTS:

Of the 16 patients, 11 had assessable responses. For local control, there were two complete and three partial responses, five with stable disease and one with progressive disease, giving a local response rate of 45% and control rate of 91%. The median survival was 23 months. The 1-year and 3-year overall survival rates were 62% and 28%, respectively. The most frequent site of recurrence was intrahepatic but outside the irradiated field. Two patients with Child-Pugh B cirrhosis developed radiation-induced liver disease. No other grade 3/4 toxicities were recorded.

CONCLUSION:

Stereotactic radiotherapy gives high local control rates and has the potential to prolong survival in patients with hepatocellular carcinoma. It is safe and tolerable in Child-Pugh A patients.

PMID:
21471590
[Indexed for MEDLINE]
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