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J Virol. 2011 Jun;85(12):6055-9. doi: 10.1128/JVI.00064-11. Epub 2011 Apr 6.

Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom.

Abstract

CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.

PMID:
21471232
PMCID:
PMC3126311
DOI:
10.1128/JVI.00064-11
[Indexed for MEDLINE]
Free PMC Article
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