Format

Send to

Choose Destination
See comment in PubMed Commons below
J Oral Maxillofac Surg. 2011 Jun;69(6):e50-7. doi: 10.1016/j.joms.2010.12.049. Epub 2011 Apr 5.

Osteochondral interface regeneration of rabbit mandibular condyle with bioactive signal gradients.

Author information

1
Bioengineering Program, University of Kansas, Lawrence, KS 66045, USA.

Abstract

PURPOSE:

Tissue engineering solutions focused on the temporomandibular joint (TMJ) have expanded in number and variety during the past decade to address the treatment of TMJ disorders. The existing data on approaches for healing small defects in the TMJ condylar cartilage and subchondral bone, however, are sparse. The purpose of the present study was thus to evaluate the performance of a novel gradient-based scaffolding approach to regenerate osteochondral defects in the rabbit mandibular condyle.

MATERIALS AND METHODS:

Miniature bioactive plugs for regeneration of small mandibular condylar defects in New Zealand white rabbits were fabricated. The plugs were constructed from poly(D,L-lactic-co-glycolic acid) microspheres with a gradient transition between cartilage-promoting and bone-promoting growth factors.

RESULTS:

At 6 weeks of healing, the results suggested that the implants provided support for the neosynthesized tissue as evidenced by the histologic and 9.4 T magnetic resonance imaging findings.

CONCLUSION:

The inclusion of bioactive factors in a gradient-based scaffolding design is a promising new treatment strategy for focal defect repair in the TMJ.

PMID:
21470747
PMCID:
PMC3101307
DOI:
10.1016/j.joms.2010.12.049
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center