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Emerg Infect Dis. 2011 Apr;17(4):668-75. doi: 10.3201/eid1704.101562.

Molecular epidemiology of Coxiella burnetii from ruminants in Q fever outbreak, the Netherlands.

Author information

1
Central Veterinary Institute, part of Wageningen UR, Lelystad, the Netherlands. hendrikjan.roest@wur.nl

Abstract

Q fever is a zoonosis caused by the bacterium Coxiella burnetii. One of the largest reported outbreaks of Q fever in humans occurred in the Netherlands starting in 2007; epidemiologic investigations identified small ruminants as the source. To determine the genetic background of C. burnetii in domestic ruminants responsible for the human Q fever outbreak, we genotyped 126 C. burnetii-positive samples from ruminants by using a 10-loci multilocus variable-number tandem-repeat analyses panel and compared them with internationally known genotypes. One unique genotype predominated in dairy goat herds and 1 sheep herd in the human Q fever outbreak area in the south of the Netherlands. On the basis of 4 loci, this genotype is similar to a human genotype from the Netherlands. This finding strengthens the probability that this genotype of C. burnetii is responsible for the human Q fever epidemic in the Netherlands.

PMID:
21470457
PMCID:
PMC3377418
DOI:
10.3201/eid1704.101562
[Indexed for MEDLINE]
Free PMC Article

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