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Semin Ophthalmol. 2011 Mar;26(2):61-3. doi: 10.3109/08820538.2011.559518.

Effect of reflux of drug during intravitreal anti-VEGF therapies on foveal thickness.

Author information

1
Department of Ophthalmology, Aintree University Hospitals NHS Trust, Liverpool, UK.

Abstract

PURPOSE:

To report any variation in foveal thickness in eyes with and without reflux during anti-VEGF injection.

METHOD:

Review of electronic case notes and scans.

RESULTS:

18 patients receiving bevazicumab were identified as having reflux (n = 3) or no reflux (n = 15). Pre-injection average central foveal thickness (CFT) was 439 microns (µ) and post-injection average CFT was 417µ. The change in mean CFT was -22 µ (range -330 to 336 µ). 70 patients receiving ranibizumab (lucentis) were identified as having reflux (n = 22) or no reflux (n = 48). Average pre-injection CFT was 336 µ and post-injection average CFT was 289 µ. The change in mean CFT was -48 µ (range -163 to 443 µ). The change in CFT between the group with reflux and no reflux in bevazicumab and ranibizumab injections was statistically insignificant.

CONCLUSION:

Reflux following injection of anti-VEGF agents does not appear to cause a sub-therapeutic effect.

PMID:
21469967
DOI:
10.3109/08820538.2011.559518
[Indexed for MEDLINE]

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