Format

Send to

Choose Destination
Protein Cell. 2011 Mar;2(3):237-49. doi: 10.1007/s13238-011-1028-z. Epub 2011 Apr 6.

The tumor suppressor RASSF1A is a novel effector of small G protein Rap1A.

Author information

1
Department of Medical Oncology, Medical Sciences Division, The University of Oxford, Oxford, UK.

Abstract

Rap1A is a small G protein implicated in a spectrum of biological processes such as cell proliferation, adhesion, differentiation, and embryogenesis. The downstream effectors through which Rap1A mediates its diverse effects are largely unknown. Here we show that Rap1A, but not the related small G proteins Rap2 or Ras, binds the tumor suppressor Ras association domain family 1A (RASSF1A) in a manner that is regulated by phosphorylation of RASSF1A. Interaction with Rap1A is shown to influence the effect of RASSF1A on microtubule behavior.

PMID:
21468893
PMCID:
PMC4875310
DOI:
10.1007/s13238-011-1028-z
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center