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Cell Biochem Biophys. 2011 Jun;60(1-2):61-8. doi: 10.1007/s12013-011-9185-5.

The multifaceted roles of USP7: new therapeutic opportunities.

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1
Progenra Inc, 277 Great Valley Parkway, Malvern, PA 19355, USA. Nicholson@progenra.com

Abstract

The deubiquitylating enzyme USP7 (HAUSP) sits at a critical node regulating the activities of numerous proteins broadly characterized as tumor suppressors, DNA repair proteins, immune responders, viral proteins, and epigenetic modulators. Aberrant USP7 activity may promote oncogenesis and viral disease making it a compelling target for therapeutic intervention. Disclosed drug discovery programs have identified inhibitors of USP7 such as P005091 with cellular proof of concept and anti-proliferative activity in cancer models. Taken together, USP7 inhibitors hold promise as a new strategy for the treatment of disease.

PMID:
21468693
DOI:
10.1007/s12013-011-9185-5
[Indexed for MEDLINE]

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