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Transcription. 2011 Mar;2(2):91-94.

Transcription factor cooperativity with heat shock factor 1.

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1
Department of Biochemistry and Molecular Biology; Yamaguchi University School of Medicine; Minami-Kogushi, Ube Japan.

Abstract

The heat shock response has been characterized by the induction of major heat shock proteins that suppress protein aggregation by facilitating protein folding. Recently, we found that mammalian heat shock factor 1, a master regulator of HSP genes, regulates non-HSP genes that suppress protein aggregation by controlling protein degradation in cooperation with the transcription factor NFAT.

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