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Transcription. 2011 Mar;2(2):78-81.

A role for phosphorylated Pol II CTD in modulating transcription coupled histone dynamics.

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Department of Biological Sciences; Oakland University; Rochester, MI USA.


Histone acetylation modulates histone occupancy both at promoters and in coding sequences. Based on our recent observation that HDACs in the budding yeast, Saccharomyces cerevisiae, are co-transcriptionally recruited to coding regions by elongating polymerases, we propose a model in which Pol II facilitates recruitment of chromatin remodeling complexes as well as other factors required for productive elongation.

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