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Transcription. 2011 Mar;2(2):55-59.

The core human mitochondrial transcription initiation complex: It only takes two to tango.

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1
Department of Pathology Yale University School of Medicine; New Haven, CT USA.

Abstract

We recently demonstrated that the core transcription initiation complex in human mitochondria is a two-component system (POLRMT and h-mtTFB2). Human mtTFA/TFAM, previously proposed to be a requisite initiation complex member, is dispensable for promoter-specific initiation in vitro. We propose that it instead regulates relative promoter activity and/or overall nucleoid transcription and replication potential.

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