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Gut Microbes. 2010 Nov-Dec;1(6):373-8. doi: 10.4161/gmic.1.6.13572.

Helicobacter pylori activation of PARP-1: usurping a versatile regulator of host cellular health.

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Department of Microbiology and the Institute for Genomic Biology, University of Illinois, Urbana, IL, USA.


Chronic infection of the human stomach by Helicobacter pylori is an important risk factor for gastric cancer. H. pylori produces a cache of virulence factors that promote colonization and persistence, which, in turn, contributes to a robust inflammatory response at the host-pathogen interface. Recently, we reported that H. pylori activates the abundant nuclear regulator poly(ADP-ribose) polymerase (PARP)-1, resulting in the production of the catabolite poly(ADP-ribose) (PAR). PARP-1 is emerging as a key player in establishing homeostasis at the host-pathogen interface. In this article, we summarize the discovery of H. pylori-dependent PARP-1 activation, and discuss potential roles for PARP-1 in H. pylori-mediated gastric disease. In light of the remarkable successes that have reported for treating inflammatory disorders and cancers with PARP-1 inhibitors, we discuss the prospects of targeting PARP-1 for treatment of H. pylori-associated gastric disease.


Helicobacter pylori; PARP-1; activation; apoptosis; cancer; inflammation

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