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Bioeng Bugs. 2010 Nov-Dec;1(6):378-84. doi: 10.4161/bbug.1.6.13086.

Engineering scalable biological systems.

Author information

1
Synthetic Biology Group,Research Lab of Electronics, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA. timlu@mit.edu

Abstract

Synthetic biology is focused on engineering biological organisms to study natural systems and to provide new solutions for pressing medical, industrial and environmental problems. At the core of engineered organisms are synthetic biological circuits that execute the tasks of sensing inputs, processing logic and performing output functions. In the last decade, significant progress has been made in developing basic designs for a wide range of biological circuits in bacteria, yeast and mammalian systems. However, significant challenges in the construction, probing, modulation and debugging of synthetic biological systems must be addressed in order to achieve scalable higher-complexity biological circuits. Furthermore, concomitant efforts to evaluate the safety and biocontainment of engineered organisms and address public and regulatory concerns will be necessary to ensure that technological advances are translated into real-world solutions.

KEYWORDS:

biological circuits; biological modulators; biological probes; engineered organisms; high-throughput design; modelling; regulatory issues; synthetic biology

PMID:
21468204
PMCID:
PMC3056087
DOI:
10.4161/bbug.1.6.13086
[Indexed for MEDLINE]
Free PMC Article
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