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Clin Infect Dis. 2011 May;52(9):1133-6. doi: 10.1093/cid/cir126.

Adult survivors of invasive pneumococcal disease exhibit defective B cell function.

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1
Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, South Yorkshire, UK.

Abstract

Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.

PMID:
21467018
PMCID:
PMC3106266
DOI:
10.1093/cid/cir126
[Indexed for MEDLINE]
Free PMC Article
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