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Hybridoma (Larchmt). 2011 Feb;30(1):11-7. doi: 10.1089/hyb.2010.0089.

Characterization of monoclonal antibodies to the plasma cell alloantigen ENPP1.

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1
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 5640 Fishers Lane, Rockville, MD 20850, USA.

Abstract

The ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1) has documented roles in mineralization, nucleotide recycling, and insulin resistance. While ENPP1 was first identified as an alloantigen on mouse plasma cells (PCs), later studies revealed expression in many tissues. Previously described monoclonal antibodies against ENPP1 expressed at the cell surface recognized cells only from mice bearing the a allotype, ENPP1(a), precluding studies of mice bearing the alternative allele, ENPP1(b). Here, we characterize a novel anti-ENPP1 monoclonal antibody that recognizes both alleles and can be used for flow cytometry.

PMID:
21466281
PMCID:
PMC3119333
DOI:
10.1089/hyb.2010.0089
[Indexed for MEDLINE]
Free PMC Article
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