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J Pediatr Hematol Oncol. 2011 May;33(4):301-5. doi: 10.1097/MPH.0b013e31820af6a8.

Imaging findings in pediatric type 1 Gaucher disease: what the clinician needs to know.

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Department of Radiology, University of Missouri School of Medicine, 1 Hospital Drive, Columbia, MO, USA.


This study presents visceral and skeletal imaging findings commonly observed in pediatric patients with type I Gaucher disease. Presented images show methods used for radiologic assessment of pediatric Gaucher patients, and imaging findings are discussed in the context of the underlying pathophysiology of the disease. Routine radiologic surveillance plays a central role in assessing Gaucher disease progression and response to treatment, but monitoring of pediatric patients presents specific challenges with regard to minimizing radiation exposure and interpreting extent of marrow involvement against the backdrop of normal growth-related changes in marrow composition. In addition to highlighting imaging findings in children with type I Gaucher disease, this manuscript discusses alternate modalities, which minimize radiation and may be just as accurate, if not better, than conventional methods exposing the child to radiation.

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