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Cancer Prev Res (Phila). 2011 Apr;4(4):481-5. doi: 10.1158/1940-6207.CAPR-10-0358.

Stress influences on anoikis.

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1
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230, USA. asood@mdanderson.org

Abstract

It long has been suspected that psychosocial factors affect cancer development and progression. Although the connections between stress and cancer causation are not strong, epidemiologic and clinical studies have provided strong links between cancer progression and several stress-related factors including chronic stress, depression, and social isolation. Recent molecular and biological studies have identified specific signaling pathways that influence cancer growth and metastasis. In particular, stress hormones can have a significant impact on protecting cancer cells from undergoing the anoikis form of programmed cell death, thus, providing a mechanistic advantage for metastasis. This review provides an overview of the relationship between psychosocial factors and the avoidance of anoikis by cancer cells.

PMID:
21464029
PMCID:
PMC3074235
DOI:
10.1158/1940-6207.CAPR-10-0358
[Indexed for MEDLINE]
Free PMC Article
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